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Sunday, July 19, 2020 | History

4 edition of Finite element modeling of drug transport processes after an intravitreal injection found in the catalog.

Finite element modeling of drug transport processes after an intravitreal injection

Finite element modeling of drug transport processes after an intravitreal injection

a study of the effects of drug-phase geometry on bioavailability and toxicity.

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Published by National Library of Canada in Ottawa .
Written in English


Edition Notes

Thesis (M.Sc.) -- University of Toronto, 1997.

SeriesCanadian theses = -- Thèses canadiennes
The Physical Object
FormatMicroform
Pagination2 microfiches : negative. --
ID Numbers
Open LibraryOL19080340M
ISBN 100612340228
OCLC/WorldCa46579313

Purpose: To evaluate the amount of drug reflux and vitreous leakage from the needle tract after various intravitreal (IVT) injection techniques in porcine cadaver eyes. Methods: The reflux after IVT injection was quantified by methylene blue injection through the pars plana of fresh pig eyes ( mL per eye, n = ) and the vitreous incarceration measured after balanced salt solution (BSS. To determine the outward permeability of retina-choroid-sclera (RCS) layer for different ophthalmic drugs and to develop correlations between drug physicochemical properties and RCS permeability. A finite volume model was developed to simulate pharmacokinetics in the eye following drug administration by intravitreal injection. The RCS permeability was determined for 32 compounds by best.

  A computer model was developed to determine drug distribution by convective-diffusive transport processes in a rabbit eye. When compared with pure diffusion within vitreous, the ratio of the amount of a model compound, fluorescein, reaching the retina to that cleared by aqueous outflow increased by 93% and 84% for intravitreal injection and. Final Report on “Intravitreal Drug Delivery: Experimentation and Mathematical the radial distance from the point of injection, and 𝑡 at the center is the time. By fitting the data and requiring a fit as The modeling process demands accurate transport property values and for this purpose, the diffusion experiments have been pet-rfec.

Fifteen (15) minutes after the intravitreal injection was given, patients were asked to rate the pain of injection from 0 (no pain/no distress) to 10 (agonizing pain/unbearable distress) using a Visual Analog Pain score survey. The results were stratified by age, gender, diagnosis, injected eye, injection . PURPOSE: To review evidence and provide updated guidelines on intravitreal (IVT) injection technique and monitoring. METHODS: A review of the published literature on IVT injection from to formed the basis for round table deliberations by an expert panel of ophthalmologists.


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Finite element modeling of drug transport processes after an intravitreal injection Download PDF EPUB FB2

Element method (FEM) to simulate the diffusion, convection, and active transport through the diffusion barriers of drugs delivered from systemic source. Jooybar et al developed a similar model with detailed geometry using FEM-based COMSOL Multiphysics for ocular drug transport following intravitreal injection and ocular implants.

Other models. Friedrich et al. and later Haghjou et al. modeled the drug distribution in rabbit eye after an intravitreous injection using the Finite Element Method and Fluent software, respectively. Quite. Park et al. developed a three-dimensional finite element method to simulate the pharmacokinetics in the entire rabbit eye following the drug administration by intravitreal injection through a controlled release implant.

All the studies reported above have assumed that the working fluid is the vitreous humor for which a porous media approximation is by: Intravitreal injection (IVI) is the most common treatment for eye posterior segment diseases such as endopthalmitis, retinitis, age-related macular degeneration, diabetic retinopathy, uveitis, and retinal detachment.

Most of the drugs used to treat vitreoretinal diseases, have a narrow concentration range in which they are effective, and may be toxic at higher concentrations. Computational modelling research has been reported to model drug transport following intravitreal injection [,[][][][], the effects of drug distribution from intraocular or.

Method: A simple mathematical model for the intravitreal transport of drugs was developed using Fick’s law of diffusion, Darcy’s law of convective flow, and Michaelis –Menten kinetics of metabolism. A Crank-Nicolson finite difference scheme of the equation describing the drug transport.

finite element models require specialized expertise in modeling, they are not accessible to most academic and industrial investigators in the field of ocular drug delivery. Therefore, we developed a simple model that is based on protein diffusion in the vitreous and its elimination via the anterior route.

Materials and Methods Computational methods have been described to model drug transport following intravitreal injection from a point source [ 22, 23, 24, 25, 26, 27] and other models have been developed to simulate drug distribution by an intraocular or periocular implant [ 25, 28, 29 ].

macular degeneration (AMD). The primary benefit of intravitreal injection is the targeting of the therapeutic agent in the eye while minimizing systemic absorption.

Inthe United States Food and Drug Administration (FDA) approved the use of the first agent for intravitreal injections, fomivirsen sodium (Vitravene®, Isis.

Methods. We developed a comprehensive three-dimensional (3D) transport model for intraocular injections using published data on drug distribution in rabbit eyes following intravitreal and suprachoroidal (SC) injection of sodium fluorescein (SF), bevacizumab, and ranibizumab. Finite Element Modeling of Dmg Transport Processes affer an lntravitreal Injection -A Study of the Effeds of Drug-Phase Geometry on Bioavailability and Toxicity Hai-Hui Lin Department of Chernical Engineering and Applied Chemistry University of Toronto Intravitreal injection of drugs is the most effective treatment of ocular diseases associated with the posterior segment of the eye.

Lin H-H. Finite element modeling of drug transport processes after an intravitreal injection—a study of the effects of drug-phase geometry on bioavailability and toxicity. Masters Thesis, Department of Chemical Engineering and Applied Chemistry, University of Toronto (). After intravitreal injection, drugs distribute within the vitreal cavity and they enter the extracellular and intracellular drug targets in the posterior eye segment.

The vitreous acts as a barrier in drug delivery, but its role is strongly dependent on the drug molecules and formulations: the barrier function ranges from insignificant to.

Update on risk of endophthalmitis after intravitreal drug injections and potential impact of elimination of topical antibiotics. Arch Ophthalmol ; 7. Storey P, Dollin M, Pitcher J, et al.

Post-Injection Endophthalmitis Study Team. The role of topical antibiotic prophylaxis to prevent endophthalmitis after intravitreal injection. In vitro models have often been used to investigate the permeability of drugs and compounds across the retinal pigmented epithelium (RPE) or to model diseases of the outer blood–retinal barrier (OBRB).

In order to obtain a physically accurate model of the OBRB, the main anatomical structures (retinal pigment epithelium, Bruch's membrane and choroid), as well as physiological conditions, such.

4 Finite Element Modeling 19 the injection moulding process. The thesis will also build knowledge of how a FE model is created and propose various strategies to shorten the cooling time in the injection moulding to transport the energy from the tool and.

A computer model was developed to describe the three-dimensional convective-diffusive transport of drug released from an intravitreal controlled release source. Unlike previous studies, this work includes flow of aqueous from the anterior to the posterior of the vitreous.

Typically, patients feel pressure, with little or no pain during the injection. After the injection, the speculum is removed and the eye is cleaned. The entire process takes about 10 to 15 minutes. Safety and results Severe complications are very rare with intravitreal injections.

The major risks are: • Infection in the eye or endophthalmitis. An intravitreal (pronounced in tra VIT re al) injection is a procedure to place a medication directly into the space in the back of the eye called the vitreous cavity, which is filled with a jelly-like fluid called the vitreous humor procedure is usually performed by a trained retina specialist in the office setting.

Download Fact Sheet Large-Print Version Spanish Translation. the eye, and the injection module inside a sterilisable dome for the injection process, as illustrated in Fig. 1(b). It allows for a fully automated intravitreal injection that is remotely started via a computer and monitored by an ophthalmic surgeon via an intuitive user interface and a visual-auditory communication system.

The wall. INJECTION dose of drug for DME Intravitreal drug AVASTIN LUCENTIS TRIAMCINOLONE Intravitreal dose mg.3 mg 2 mg strength in vial 25 mg / ml 10 mg / ml 40 mg / ml Amt in cc injected ml ml ml To be repeated after 1 month 1 month 3 to 4 months NUMBER OF INJ PER VIAL 50 1 1 Cost per inj thousand rs (DOCTOR COST less than   Intravitreal injection has become an increasingly employed tool in the management of posterior segment diseases.

Clinical experience with IVT injections has provided substantial data concerning the safety of this pro­cedure. In two controlled trials leading to Food and Drug Administration ap­prov­­al of fomivirsen and hy­a­lu­ro­ni.PigmentedRabbit Injection(center) U£(Jn ) [2] AlbinoRabbit Implant- 6m!!(and Jl¥h) [3] Human Injection(center) W!(in ) [4] * GCV location is closer to hyaloid membrane Table 1.

In vivo studies for intravitreal GCV transport In order to evaluate the convection-diffusion drug transport.